Phytozine Ringworm Treatment
Phytozine is a natural ringworm treatment available over the counter and is marketed as a fast-acting cure for ringworm infections. Among the ingredients listed include FDA-approved 1% tolnaftate as well as tea tree oil, camphor, lavender, jasmine and clove. Tolnaftate is also the same active ingredient in the over the counter Tinactin spray for athlete’s foot.
In conjunction with these antifungal active ingredients, Phytozine also includes components to help soothe the skin including aloe vera, sweet almond oil, rose oil, cocoa butter and oat kernel.
Although marketed as a treatment and cure for ringworm, Phytozine antifungal cream may also be used for a variety of similar ringworm or “tinea” infections on the skin. This is due to the fact that it’s mechanism of action targets not only the fungi that cause ringworm, but also aspects relevant to all or most fungal skin infections.
Additionally, the major active ingredient in Phytozine, tolnaftate, is also available over-the-counter under several brand names: two more common ones include Lamisil AF cream and Tinactin spray and cream. Both brand name products are marketed as cures for athlete’s foot (tinea pedis).
Is Phytozine safe?
One of the more active antifungal ingredients in Phytozine is tolnaftate. This compound works by interfering with fungal ergosterol synthesis (via squalene epoxidase) [1, 2]. Since this process is only present within fungal cells (the human analog is cholesterol), the drug should only target the ringworm fungal cells specifically. It is not surprising that major side effects have not been reported in the literature when tested for topical toxicity [3, 4].
The additional natural antifungal ingredients contained within Phytozine cream have also been shown to be safe when applied topically. Tea tree oil , camphor , lavender , jasmine , and clove have all been shown to be effective and safe antifungal agents.
How to Use
Phytozine is available over the counter as a 1% tolnaftate cream. It is recommended to wash the affected area and to dry it thoroughly before use. Apply the cream twice daily to the affected area plus a few centimeters beyond the outer ringworm infection for at least four weeks. The ringworm infection may soon disappear before the recommended treatment time is complete, but it is advised to continue treatment well after these visual symptoms subside. Do not cover the treated area with bandages or anything that may prevent the circulation of air, and it is generally recommended to wear loose fitting clothing around the area. Although tolnaftate can be used to treat other tinea infections (e.g. ringworm of the scalp or nails), this particular cream may not be as effective as other forms of the ingredient.
Additional Natural Ringworm Treatments
Tolnaftate is a synthetic antifungal treatment that is used in creams, gels, lotions, etc. and often combined with naturally occurring compounds. For information on purely natural compounds and home remedies for ringworm infections, see Home Remedies for Ringworm and Tinea Infections.
“This is definitely worth spending the $40 for. I had ringworm in several places (and it was spreading) for a several weeks and tried an over-the-counter anti-fungal spray that didn’t work. Within a few days, Phytozine started working. After a week, it is close to being gone. Definitely recommend this product.” by “R&B McD” (Amazon Inc, 2014)
“Amazing! used various treatments for one year and THIS is the one. Ringworm gone 1 week!!!” by “David Meek” (Amazon Inc, 2014)
“Have recommended this to multiple friends and moms of little wrestlers. It is the only thing that worked in my household on a stubborn case of ringworm.” by “Carla” (Amazon Inc, 2014)
“This product worked really well. Stopped itching and made blotchy patches disappear fairly quickly. I’ve tried other products and have sensitive skin. Had burning with other products but not with this one. I’d purchase again as needed.” by “Howard Feldman” (Amazon Inc, 2013)
 Ryder NS, Frank I, Dupont MC. Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986 May;29(5):858-60. Full text.
 Georgopapadakou NH, Bertasso A. Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother. 1992 Aug;36(8):1779-81. Full text.
 Millikan LE. Current concepts in systemic and topical therapy for superficial mycoses. Clin Dermatol. 2010 Mar 4;28(2):212-6. Link.
 Tom LW. Ototoxicity of common topical antimycotic preparations. Laryngoscope. 2000 Apr;110(4):509-16. Link.
 Homeyer DC, Sanchez CJ, Mende K, Beckius ML, Murray CK, Wenke JC, Akers KS. In Vitro activity of Melaleuca alternifolia (tea tree) oil on filamentous fungi and toxicity to human cells. Med Mycol. 2015 Apr 1;53(3):285-94. Link.
 Abu-Darwish MS, Cabral C, Ferreira IV, Gonçalves MJ, Cavaleiro C, Cruz MT, Al-bdour TH, Salgueiro L. Essential oil of common sage (Salvia officinalis L.) from Jordan: assessment of safety in mammalian cells and its antifungal and anti-inflammatory potential. Biomed Res Int. 2013;2013. Full text.
 Nardoni S, Mugnaini L, Pistelli L, Leonardi M, Sanna V, Perrucci S, Pisseri F, Mancianti F. Clinical and mycological evaluation of an herbal antifungal formulation in canine Malassezia dermatitis. J Mycol Med. 2014 Sep;24(3):234-40. Link.
 Wellness.com: Jasmine dosing and safety. Link.
 WebMD.com: Clove oil side effects. Link.